Click Go! and then just keep clicking one of the three polynomial buttons.

Let's say you click on x^{2} + 5x + 6. Since x^{2} + 5x + 6 factors into (x + 2) * (x + 3), this causes the (x + 2) column and the (x + 3) column to grow one block higher.
If you complete a row, the row disappears and any remaining blocks shift down. Try to complete as many rows as you can.
Each time you click a number, time is added to your timer.
If a column grows beyond the game board, or if time runs out, it's game over. Have fun!